Spontaneous carotid artery dissection as a cause of stroke in a patient with factor V Leiden mutation: a case report and review of the literature

A 36 year old male soldier underwent colour doppler ultrasound [CDU] study of carotid arteries after sudden onset of left sided weakness The investigation revealed dissection of the right internal carotid artery [ICA]. assessment of the coagulation status showed that our patient has homozygotic mutation of factor V Leiden.This observation is the third reported case of ICA dissection occurring in a patient with factor V Leiden and the first of ICA dissection in association with homozygotic mutation of factor V Leiden mutation

Spontaneous internal jugular vein thrombosis in association with factor V Leiden: a case report

We report an unusual case of internal jugular vein thrombosis in a 33-year-old female patient who presented with a right-sided painful neck swelling. Diagnosis was proven by color Doppler ultrasonographic examination. Thrombosis screen revealed that the patient had heterozygotic mutation of factor V Leiden. Causes of internal jugular vein thrombosis are reviewed. The molecular basis of this mutation is described, and the importance of screening for hereditary thrombosis states is highlighted

Behcet's disease: brain imaging findings

To evaluate the pattern and site of brain involvement in neuro-Behcet's disease. Twenty patients with Behcet's disease, four with neurological manifestations and 16 patients without neurological manifestations were evaluated. T1 weighted and T2 weighted magnetic resonance imaging as well as magnetic resonance angiography and magnetic resonance venography images were obtained for all patients. Non-enhanced axial computerized tomography was performed only for the four patients with neurological manifestations. Four out of 20 patients [20%] with neurological symptoms showed abnormal radiological findings. The changes were seen in the basal ganglia, thalamus, brain stem and cerebellum. The abnormal changes were high signal intensity in T2 weighted magnetic resonance imaging and low signal intensity in T1 weighted magnetic resonance imaging, the abnormalities on computerized tomography scan were low-density lesions. The magnetic resonance imaging for the other 16 patients [80%] neurological in asymptomatic were normal. Magnetic resonance imaging and computerized tomography play a major role in the diagnosis of brain involvement in Behcet's disease. The basal ganglia, thalamus, brain stem and cerebellum are the commonest sites of involvement. Imaging does not seem to be of value in neurologically asymptomatic patients